Pertuzumab is also licensed as neoadjuvant treatment for patients with HER2-positive early breast cancer (EBC); approval was supported by two phase II studies, NeoSphere (NCT00545688) and TRYPHAENA (NCT00976989), in which the addition of pertuzumab to trastuzumab and chemotherapy significantly improved pathologic complete response rate (pCR), without increasing cardiac toxicities [8, 9]. This evidence concerns the gene ERBB2 and breast cancer.