It is postulated that nucleic acids sensing other PRRs apart from TLRs such as AIM2-like receptors, retinoic acid-inducible gene-1 (RIG-1)-like ones and others participate in development of colitis and subsequently cancer due to the release inflammatory cytokines and the induction of inflammatory milieu (He et al. 2017). The gene discussed is PLAAT4; the disease is cancer.