Other immune-stimulating effects of platinum-based drugs include increased major histocompatibility complex (MHC) class I expression and sensitizing tumor cells to granzyme-B-mediated cytotoxic T cell killing.12, 25 Based on these findings, it is well acknowledged that platinum-based chemotherapy promotes the development of tumor-specific immunity and combining with immune checkpoint blockade may boost the function of effector T cells (Figure 1). Here, GZMB is linked to neoplasm.