CNPY2 and colorectal carcinoma: In recent years, a growing number of independent indicators in CRC have been explored, such as serum pentraxin-3 (Liu, Zhao & Guo, 2018), CNPY2 (Peng et al., 2018), and HSP-90α (Kasanga et al., 2018), which have been of great help in the diagnosis and prognosis of CRC; however, the reliability of these biomarkers requires further study.