IL6 and colorectal carcinoma: Using a meta-analysis method, IL-6, platelet- lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) were able to predict the prognosis of CRC, with a hazard ratio (HR) of 1.76, 1.89, and 1.56 for OS, and 2.97, 1.49, and 1.92 for DFS, respectively (Xu et al., 2016; Zhang et al., 2017).