SOD1 and amyotrophic lateral sclerosis: Consistent with the notion that upregulation of chemokines in CNS may contribute to the infiltration of periphery immune cells, increased expression of Ccl2 in SOD1 mutant transgenic mice or ALS patients has been reported to induce the infiltration of dendritic cells and promote the acquisition of properties of antigen-presenting cells by microglia [48–50].