Since ALS-causing mutations in SOD1 gene were reported in 1993 [2], more than 50 ALS-associated genes have been subsequently reported, including TARDBP, encoding TAR DNA-binding protein 43 (TDP43) [3], FUS [4, 5], C9orf72 [6, 7]. Here, TARDBP is linked to amyotrophic lateral sclerosis.