For example, [5] analyzed 12 cancer types and identified subnetworks (e.g., a TP53 subnetwork) mutated in most cancer types as well as subnetworks (e.g., a MHC subnetwork) enriched for mutations in one cancer type. In addition, comparative analyses may also be used for the identification of mutations of clinical relevance [12]. The gene discussed is HLA-C; the disease is cancer.