We first considered single genes, identifying TP53 with high (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$>0.5$$\end{document}>0.5) differential coverage between the two cancer types. The gene discussed is TP53; the disease is cancer.