Till now, the ten members of TMED family have been discovered [5]; many TMED proteins [6–9] have been investigated and reported except for TMED3 which has been comparatively seldom described in the context of cancer, with the exception of the only three relevant studies performed regarding TMED3 in cancers, including prostate cancer [10], colon cancer [11] and liver cancer [12]. The gene discussed is TMED3; the disease is liver cancer.