In stark contrast with the observation by Duquet et al., Zheng et al. reported that up-regulated TMED remarkably correlated with aggressive malignant behaviors and poor prognosis in patients with hepatocellular carcinoma and TMED3 was shown to promote cell migration and invasion through IL-11/STAT3 signaling pathway [12]. The gene discussed is STAT3; the disease is hepatocellular carcinoma.