We recently found that expression of the E3 ubiquitin ligase NEDD4 (also named as NEDD4-1) and the Hippo-YAP/WWTR1 (commonly listed as TAZ) signaling target gene product CYR61 (also named as CCN1) is significantly associated with metastasis of GCA and correlated with poor survival of GCA patients [19, 20]. The gene discussed is WWTR1; the disease is temporal arteritis.