In some tumor cell types, E-cadherin expression is reduced by overexpression of the transcriptional repressor Snail31 Exposing NCI-H522 to the Snail inhibitor GN2532 also blocked killing by compound 4, however we did not detect E-cadherin re-expression (Fig. 8; our unpublished data). This evidence concerns the gene SNAI1 and neoplasm.