GSDMD and colorectal cancer: Furthermore, expression of GSDMA, GSDMC, and GSDMD was found to be downregulated in primary esophageal squamous cell carcinoma and gastric cancer tumors19, and expression of GSDME has been shown to be downregulated in breast, gastric, and colorectal cancers due to promoter hypermethylation17,18,21,22.