Metadherin (Mtdh), also known as lysine-rich CEACAM1 co-isolated (LYRIC)/3D3 and astrocyte elevated gene-1 (AEG-1), was initially discovered as an oncogene that is upregulated in various types of cancers, such as breast carcinoma and hepatoma [19, 20]. This evidence concerns the gene MTDH and hepatocellular carcinoma.