PIK3CA and breast cancer: For the BC mutation data, AWRMP identified the parsimonious set (AKT1, BRCA2, GATA3, MAP3K1, PIK3CA TP53, RGS1(A), where “(A)” refers to amplification) with a high coverage score of 0.86 and a low overlap score of 0.45 (Supplementary Fig. 3).