PTGS1 and Pain: In terms of neuropathic pain, three disease proteins of neuropathic pain can be directly targeted by FFDS, including TNF45, PTGS146 and PTGS247; twenty therapeutic targets of drugs with indications including neuropathic pain can be directly affected by FFDS, such as PTGS2, PTGS1 and 5-hydroxytryptamine receptor 3A (HTR3A), which have all been associated with at least four drugs known for the treatment of neuropathic pain.