Vascular cell adhesion protein 1 (VCAM1), which is not a pain disease protein, can directly interact with the most pain disease proteins (6), followed by NF-kappa B inhibitor alpha (NFKBIA) (5), mitogen-activated protein kinase 3 (MAPK3) (5) and inhibitor of nuclear factor kappa B kinase subunit beta (IKBKB) (4). The gene discussed is PROS1; the disease is glycogen storage disease VI.