Among the 27 secondary pain disease proteins that have direct interactions with the pain disease protein set, high affinity nerve growth factor receptor (NTRK1) can interact with the most pain disease proteins (14) directly, followed by transitional endoplasmic reticulum ATPase (VCP) (11), heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) (9) and RNA-binding protein FUS (FUS) (8). The gene discussed is NGFR; the disease is glycogen storage disease VI.