Additionally, we found that the levels of SMC3 acetylation were impaired in cancer cells lines harboring STAG2 inactivation (H4 parental and TC-106 STAG2 knockout cells) relative to their STAG2 wildtype counterparts (H4 STAG2 knock-in and TC-106 parental cells) (Fig. 5j). The gene discussed is STAG2; the disease is cancer.