SMC3 and glioblastoma: As we observed disruption of SMC3 acetylation following STAG2 depletion in TP53-wildtype cells that is known to be required for establishment of sister chromatid cohesion during DNA replication, we investigated the status of SMC3 acetylation in RPE cells after dual depletion of STAG2 and TP53, as well as in paired isogenic STAG2 glioblastoma (H4) and Ewing sarcoma (TC-106) cell lines.