We had previously shown that the combined treatment BETi + IMiDs can further repress mRNA expression of IRF4 and enhance the expression of the NKG2DL MICA in MM, suggesting that CRBN-mediated degradation of IKZF1/3 cooperates with BETi mediated repression of IRF4/MYC in this pathway38. This evidence concerns the gene MYC and Miyoshi myopathy.