These data could explain, at the same time, the two main findings described above: increased apoptosis and lower resistance to anti-MM drugs (protective role mediated by IRF4, MYC, IKZF1/3), and the higher expression of NK cell-activating ligands in the presence of IMiDs (repressive role of IRF4, IKZF1 on NK cell-activating ligands), caused by reduced MEIS2 expression in these cells. This evidence concerns the gene IRF4 and Miyoshi myopathy.