In this regard, Gene Ontology enrichment analysis over transcripts significantly correlated with MEIS2 [MM dataset of R2 (Hanamura)]42, highlighted several gene clusters related to apoptosis, ER homeostasis, mitochondrial functions and senescence, supporting the hypothesis of multiple regulatory roles mediated by MEIS2 in critical aspects of MM biology (Supplementary Figure 3). Here, MEIS2 is linked to Miyoshi myopathy.