In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1β), and hypoxia-responsive (HIF1α and GAPDH) genes between LOsG- and sham-treated groups. Here, HIF1A is linked to prediabetes syndrome.