Thus, to identify potential target genes that could be regulated by miR-506 in RA-FLSs, the PicTar, TargetScan, and miRanda bioinformatic databases were used, and based on a binding sequence at 300–306 bp of TLR4 3′-UTR, a potential target for miR-506 was selected (Figure 5A). The gene discussed is TLR4; the disease is rheumatoid arthritis.