It has been indicated that heterozygous germline mutations of MRN complex can be potentially capable of developing different types of cancers such as breast and ovarian cancers such as BC and ovarian cancer (OC) [192, 193, 196], indicating that carrier of a deleterious mutation in NBN may be capable of increasing the risk about two- to threefold [192]; however, its role is controversial. This evidence concerns the gene NBN and ovarian cancer.