Also, promoter methylation profiles of a few established candidate genes of PCOS including yes-associated protein (YAP1), follistatin (FST), aromatase (CYP19A1) and  luteinizing hormone chorionic gonadotropin receptor (LHCGR) have been investigated in these cells, and ovarian tissues by some groups till date [10–14]. This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.