MAPK8 and posterior cortical atrophy: To further decipher whether MAPKs mediate Spautin-1 induction of growth inhibition, cell viability assay was performed on PCa cells post Spautin-1 treatment in the presence or absence of SP600125 (JNK inhibitor), SB230580(p38 inhibitor), or LY3214996 (ERK inhibitor).