Analysis of the same set of patient data using a multivariate Cox proportional hazards model showed that tumor size (P = 0.008; HR, 5.854; 95% CI, 1.587–21.597) and EHD1 expression (P = 0.007; HR, 6.372; 95% CI, 1.645–24.676) were independent prognostic indicators of OS in osteosarcoma patients (Table 3). This evidence concerns the gene EHD1 and osteosarcoma.