Furthermore, compared to reported MCC950 studies done by Xu et al. [26], MCC950 was given during the entire experimental period up to 21 days post-injury, whereas in our study, JC124 was given only during the first 30 h post-injury when NLRP3 inflammasome activation was trigged by brain injury suggesting the benefits of direct inhibition of the inflammasome complex by our novel compound. The gene discussed is NLRP3; the disease is brain injury.