NLRP3 inflammasome which consists with the NLRP3 scaffold, the apoptotic speck-containing protein (ASC) adaptor and caspase-1, has been reported to associate with neuroinflammation in Alzheimer’s disease (AD) [8–10], Huntington’s disease [11], and pneumococcal meningitis [12]. Here, NLRP3 is linked to pneumococcal meningitis.