Intriguingly, the levels of activated/phosphorylated AKT, (p-AKTS473) were lower in E545K/c-Met HCC from Sgk3+/+ mice than those from Sgk3−/− mice (Fig. 5b); whereas p-AKTT308 was consistent in all HCC samples tested. Here, SGK3 is linked to hepatocellular carcinoma.