As AKT2 depletion strongly suppresses de novo lipid biosynthesis and Fasn ablation impairs E545K/c-Met or H1047R/c-Met in mice (Che L et al., manuscript in preparation), these data might explain the different anti-neoplastic effect of AKT2 and SGK3 on the growth of HCC with PIK3CA mutations. Here, PIK3CA is linked to hepatocellular carcinoma.