However, although the values of physique-related factors were significantly lower in the switch-group than in the pirfenidone-naïve group in the present study, only nintedanib-induced anorexia was significantly more frequent and severer in the switch-group than in the pirfenidone-naïve group, whereas no significant differences were observed in other AEs such as diarrhea and AST/ALT elevation. This evidence concerns the gene GPT and Anorexia.