The most common AE of nintedanib was AST / ALT elevation (63.3%), followed by anorexia (46.7%), diarrhea (46.7%), and weight loss (20.0%), whereas the most common CTCAE grade ≥ 2 AE was anorexia (36.7%), followed by diarrhea (26.7%) and AST/ALT elevation (23.3%). The gene discussed is GPT; the disease is Anorexia.