In order to investigate some of the benefits of leucine-rich diet over the damage effects of tumour development on muscle protein, here we analysed the profile of these same key proteins of mTOR signalling pathway, including phosphorylated proteins, from up-stream and down-stream steps, which provided some interesting point how the leucine-rich diet could modulate the tumour-induced damages in this experimental model of cachexia. This evidence concerns the gene MTOR and neoplasm.