MTOR and neoplasm: In spite of the evidence that mTOR was not permanently increased in the L group, suggesting an adaptive process that reached a steady state following 3 weeks of leucine-rich dietary supplementation, the WL tumour-bearing group showed that RAG-A facilitated the stimulation of the mTOR pathway, confirming the muscle response in the WL group that was noted in previous studies [7, 10, 39, 40].