The renoprotective role of human recombinant extracellular superoxide dismutase (EC-SOD) on DKD—amelioration of hyperglycemia-induced oxidative stress, inflammation, and apoptosis through the activation AMPK-PGC1α-nuclear factor erythroid 2-related factor 2 (Nrf2) and AMPK-FoxOs pathways—was also demonstrated in our recent study [41]. The gene discussed is PPARGC1A; the disease is diabetic kidney disease.