IGHE and autoimmune disease: This shift towards Th17 in regularly vaccinated humans was quite possible as Th17 cell-mediated human immunity proved suppressing the IgE responses was associated with human autoimmune disease [50,51], because class switch recombination to both IgG4 and IgE depends on the production of the Th2 cytokines, particularly IL-4 and should correlate with elevated IL-10 [52].