GADD45A and cancer: Also TRIM3, that has been reported as a tumour suppressor in different cancers, such as glioblastoma, liver, cervical and colorectal cancers, exerts (at least partially) its role in controlling cell proliferation, migration and invasion of cancer cells by increasing p53 stability (Figure 2), with concomitant induction of transcriptional activity of downstream target genes, p21 and GADD45 [48].