An association between HOX expression and poor prognosis has already been established for breast cancer and lung adenocarcinoma (HOXB7), renal clear cell carcinoma (HOXC11), mesothelioma (HOXB4), oral squamous cell carcinoma (HOXD13), gastric cancer (HOXC6), thyroid cancer (HOXC10), bladder cancer (HOXB13), and AML (HOXA9) [101]. The gene discussed is HOXA9; the disease is acute myeloid leukemia.