F2 and hemorrhagic fever with renal syndrome: A decreased plasma activity of coagulation factors II, V, VIII, IX, and X in acute HFRS patients, prolongation of the prothrombin and activated partial thromboplastin time, increased thrombin generation and D-dimer levels, and a decrease in ADAMTS13 activity were observed in PUUV-infected patients [22,23,24,25].