For example, Topiramate prolongs mitochondrial survival, increases the activity of the mitochondrial respiratory chain complex [114], protects against oxidative stress, inflammation [115] and mitochondrial membrane depolarization, and has an insulin-sensitizing effect on adipocytes in female rats [116]; Amitriptyline also increases antioxidant capacity and reduces markers of oxidative stress [117] and Valproate preserves mitochondrial function in a rat model of migraine [118] and increases mitochondrial biogenesis [119]. This evidence concerns the gene INS and migraine disorder.