Further support for a generalized metabolic dysfunction in migraine comes from the reduced activity of mitochondrial enzymes, such as monoamine-oxidase, succinate-dehydrogenase, NADH-dehydrogenase, cyclooxygenase (COX) and citrate-synthetase in the platelets of migraine patients with and without aura [92,93]. This evidence concerns the gene ENSG00000251605 and migraine disorder.