Most importantly, calcitonin gene related peptide (CGRP) [189,190,191,192,193] see review [194], but also substance P, vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), nitric oxide (NO) [135,195,196,197,198] and to some extent cytokines [199], are all molecules associated with migraine both in animal and human studies review [187,200]. This evidence concerns the gene VIP and migraine disorder.