HSPA5 and malignant colon neoplasm: To explore the ability of EtOH to activate ER stress in colon cancer cells, we analyzed the levels of glucose-regulated protein of 78 kDa (GRP78), which is a chaperone interacting with misfolded proteins and an indicator of ER stress, and CCAAT/enhancer-binding protein homologous protein (CHOP), a transcriptional factor which promotes apoptosis under prolonged ER stress [32].