Thus, the administration of both APC and the signaling-selective APC-2Cys [69], but not the anticoagulant-selective and signaling-defective APC-E170A [70], reduced myocardial infarction and restored cardiac function in the ischemic mouse heart by activating AMPK in both in vivo and ex vivo model systems [68]. The gene discussed is APC; the disease is myocardial infarction.