Together, these results suggest that the negative effect of exogenous VEGF in NO‐Tie mice recovery from blood flow may be paralleled by, but is not synergistic with, Notch1 activation, and that the quality of the revascularization in terms of the balance between the temporal and spatial development of arterioles vs capillaries is critical for effective recovery from ischemia. The gene discussed is NOTCH1; the disease is ischemia.