Rac‐1 was reported to promote cellular proliferation of human colon cancer by up‐regulating the Jun N‐terminal kinase 2–C‐Jun–cyclin D1 pathway 41 and promote mitochondrial motion by causing the phosphorylation of vimentin 42, which suggested that Rac‐1 might provoke cellular proliferation and metastasis by regulating cyclin D1 and vimentin. This evidence concerns the gene JUN and malignant colon neoplasm.