In the TIME study (“Tarceva as second-line treatment after pemetrexed in advanced NSCLC”), we aimed to address this issue and assess the effectiveness, safety and tolerability of erlotinib as second-line treatment in EGFR mutation unselected patients with advanced non-squamous NSCLC after failure of a first-line pemetrexed-containing chemotherapy regimen. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.