Epidemiological survey data indicate that the most frequently mutated genes identified in patients with NSHL in China include GJB2 (OMIM: 121011), SLC26A4 (OMIM: 605646), and the mitochondrial gene MT-RNR1 (OMIM: 561000) and that each of these genes have multiple common mutations. The gene discussed is GJB2; the disease is nodular sclerosis classical Hodgkin lymphoma.