CXCL9 and metastatic malignant neoplasm in the lymph nodes: In Ruehlmann’s study, he demonstrated that CXCL9 chemokine gene therapy which aided by small but non-curative doses of huKS1/4-IL-2 can suppressed the growth of murine colorectal carcinoma and inhibiting their pulmonary metastases [26].Zhenqian Wu et al showed the expression of CXCL9 was significantly associated with tumor differentiation, tumor invasion, lymph node metastasis, distant metastasis, and vascular invasion[27].K.