The results demonstrated that polyphenols induce CXCR3 expression on regulatory T cells and increases CXCR3 ligands (CXCL9, CXCL10, CXCL11) in tumor microenvironment, it may become an important regulator in the treatment of CRC[33]. The gene discussed is CXCL11; the disease is colorectal carcinoma.