E2F1 and central nervous system cancer: For instance, lncRNA CASC9 is highly expressed in glioma specimens and the ectopic overexpression modulates the proliferative ability, invasion in vitro and mechanically sponged miR‐519d/STAT3 positive feedback loop.9 Furthermore, DLX6‐AS1 accelerates the tumour phenotype of glioma via miR‐197‐5p targeting the E2F1 gene, constructing DLX6‐AS1‐miR‐197‐5p‐E2F1 axis.10 These evidence shows the diverse cellular pathophysiological process in the glioma, such as differentiation, metastasis and angiogenesis.