PMS is a syndromic form of ASD characterized by gene deletions affecting the human chromosomal region 22q13.3 (Phelan and McDermid, 2012), particularly the neuronal structural gene SHANK3. Individuals with PMS have high rates of intellectual disability, difficulties in communication and motor function, and approximately 84% fit the core diagnostic criteria for ASD (Soorya et al., 2013). Here, SHANK3 is linked to premenstrual tension.