Altered BK channel function has been repeatedly linked to neurological disease including idiopathic generalized epilepsy (Lorenz et al., 2007), non-kinesigenic dyskinesia (Du et al., 2005) and Alzheimer’s disease (Beecham et al., 2009; Burns et al., 2011; Beecham et al., 2014). This evidence concerns the gene KCNMA1 and Alzheimer disease.