Noteworthy, variants in genes responsible for oligodontia and ectodermal dysplasia (e.g., PAX9, EDA, MSX1, AXIN2, EDARADD, NEMO, and KRT17) (Ye & Attaie, 2016) were not detected by either the targeted sequencing or WES. Here, MSX1 is linked to ectodermal dysplasia syndrome.