Consistent with our study, another team showed that polydatin could ameliorate high‐fat diet‐induced NASH in terms of lipid peroxidation and inflammation.39 Our data further suggested that polydatin could exert its therapeutic effect in NASH by up‐regulating the transcription factor TFEB and subsequently restoring the lysosomal clearance of autophagosomes. This evidence concerns the gene TFEB and metabolic dysfunction-associated steatohepatitis.