In this study, we examined the therapeutic effect of polydatin in the experimental steatohepatitis model using a nutritional model of NASH (ie db/db mice fed MCD diet), demonstrating that this phytochemical could reduce liver damage and lipid accumulation as evidenced by diminished NAFLD activity score, along with reduced serum cholesterol and ALT levels. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.