The effects of polydatin alone on LC3B‐II and SQSTM1/p62 protein levels in LO2 cells were shown in the left panel of Figure S1A. These findings suggested the mechanistic action of polydatin in restoring autophagic flux in NASH, presumably by promoting autophagosome–lysosome fusion or increasing the lysosome‐dependent degradation. This evidence concerns the gene SQSTM1 and metabolic dysfunction-associated steatohepatitis.