Our recent study suggests that autophagy is impaired in NAFLD/NASH as a result of defective lysosome acidification.9 MiT‐TFE family transcription factors, including TFEB, TFE3 and MITF, contribute to modulation of lysosome biogenesis, cellular energy homeostasis, and regulation of autophagy.34 Among these transcriptional factors, TFEB is a master regulator of autophagy by promoting lysosomal biogenesis and functions 35 and therefore could be a promising therapeutic target. Here, TFE3 is linked to metabolic dysfunction-associated steatotic liver disease.