LEPR and metabolic dysfunction-associated steatohepatitis: To elucidate the action of polydatin in the development of steatohepatitis, we first used a genetic mutation model (db/db mice), which has a point mutation in leptin receptor, and fed MCD diet to mimic the pathogenesis and aetiology of human NASH.22, 23 We demonstrated that oral gavage of polydatin (100 mg/kg) every other day for 4 weeks reduced NAFLD activity score 21, 24 (Figure 1A,B) as well as liver levels of triglyceride (Figure 1C) accompanied by reduced liver levels of cholesterol (Figure 1D).