TRERF1 and Sjogren syndrome: Shah et al found that Rapa had a significant anti‐inflammatory effect in a Sjögren's syndrome mouse model, which inhibited lacrimal gland inflammation and improved ocular surface conditions.37 Nevertheless, Rapa is also a potent activator of mTOR‐dependent autophagy.38 In our mouse model, following injection of the autophagy activator, Rapa significantly decreased the number of apoptotic cells (Figure 6) which likely suggests that Rapa promotes ocular surface healing through affecting autophagy in this model.