Our previous study found that Pmp53 could increase the sensitivity of ovarian cancer to cisplatin.22 Here, we treated DU145 and PC3 cells with zinc, or PTX and/or Pmp53, the western blot results showed that after transfected with Pmp53, the expression of p53 was increased and the expression of MDM2 was decreased (Figure 2A). This evidence concerns the gene MDM2 and ovarian carcinoma.