MDM2 and ovarian cancer: Our previous study found that Pmp53 could increase the sensitivity of ovarian cancer to cisplatin.22 Here, we treated DU145 and PC3 cells with zinc, or PTX and/or Pmp53, the western blot results showed that after transfected with Pmp53, the expression of p53 was increased and the expression of MDM2 was decreased (Figure 2A).