TNFRSF11B and osteoarthritis, knee: To sum up, our study provides evidence for associations between the nine SNPs (rs1485286, rs1905786, rs1032128, rs3134056, rs3134058, rs11573828, rs1564861, rs3134053, and rs11573849) of OPG from the OPG/RANK/RANKL system and the risk of knee osteoarthritis.