It is well known that, OPG/RANKL/RANK signaling pathway belongs to the TNF receptor (TNFR) superfamily and also played a crucial role in bone metabolism and osteopathy development, including inherited bone diseases, acquired bone pathologies, osteoarthritis, and osteonecrosis(Di et al., 2015; Kwan Tat et al., 2009; Walsh & Choi, 2014). The gene discussed is TNFRSF11B; the disease is osteonecrosis.