Specially, a panel of eight serum tumor markers (AFP, β‐HCG, CA125, CA15‐3, CA19‐9, CA242, CEA, and HE4) showed a good performance in prediction of BRCA1 mutation carriers (AUC = 0.974, Sensitivity = 0.714, Specificity = 1.000). The gene discussed is AFP; the disease is neoplasm.