While only considering 61 ovarian cancer patients and 60 controls with HE4 serum levels, HE4 as a single marker showed a comparable performance in ovarian cancer detection (AUC = 0.767, Sensitivity = 0.541, Specificity = 0.933) to that of CA125 (AUC = 0.802, Sensitivity = 0.541, Specificity = 0.883), and the previous 8‐marker panel plus HE4 showed an improved performance in ovarian cancer detection (AUC = 0.916, Sensitivity = 0.770, Specificity = 0.900) (Table 4, Figure 1c). Here, WFDC2 is linked to ovarian carcinoma.