However, short‐term therapies can reduce inpatient mortality and morbidity, which is sustained in the longer term in patients with acute myocardial infarction.4 It is, therefore, not impossible that short‐term treatment can have long‐term benefit, but demonstration of the small effects of beta‐blockers4 and angiotensin‐converting enzyme inhibitors5 in acute myocardial infarction required the randomization of large numbers of patients. The gene discussed is ACE; the disease is myocardial infarction.