THBS4 and major depressive disorder: Regarding Ala387Pro variants of the THBS4 gene, there was a higher prevalence of hypertension for GG + GC compared to CC carriers (95.8% vs. 4.2%, p = 0.016) and a lower prevalence of depression for CC + GC carriers compared with to GG carriers (31.9% vs. 68.1%, p = 0.019).