BCL2 and acute myeloid leukemia: Cotreatment of primary AML blasts and AML cell line xenografts with venetoclax and the PI3 kinase/mTOR inhibitor GDC-0980 also resulted in enhanced apoptosis, involving MCL-1 downregulation and Bax activation, suggesting that coadministration of PI3K and BCL-2 inhibitors may be effective in AML treatment (43).